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Switzerland

Prof. Edna Grünblatt heads the Translational Molecular Psychiatry research in the Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich (PUK), Switzerland. Additionally, she serves as the Chair of the ECNP iPSC platform for Neuropsychiatry Network. The primary area of her research is neurodevelopmental mental disorders, with a particular focus on attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), psychosis (including schizophrenia), and early onset obsessive-compulsive disorder (OCD). Her group is currently carrying out investigations on the potential molecular and cellular link between ADHD and Alzheimer's disease across the lifetime. Her group does research in both pre-clinical and fundamental molecular neuroscience, using both approaches in translational research. The employed methodologies encompass molecular genetics, epigenetics, neuro-psycho-pharmacology, neuronal cellular models, and biochemical analyses. Their study aims to clarify the underlying causes and mechanisms of the disorders by identifying biomarkers that may be used for early diagnosis and personalized medication. Additionally, they seek to anticipate how patients will respond to treatment and what the consequences of the treatment will be. Currently, she has established patient specific iPSC (induced pluripotent stem cell) neuronal modelling to enable personalized medicine, via studies of the neuronal/molecular alterations in a dish, in an “ex vivo” manner. This model provides a non-invasive approach to investigate etiopathology of neurodevelopmental disorders as well as test drug therapy and develop new therapy approaches.

Reseachers - Switzerland